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KMID : 0896020070370010053
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Korean Journal of Oral and Maxillofacial Radiology
2007 Volume.37 No. 1 p.53 ~ p.59
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Analysis on correlation between bone strength by FEA, micro-CT parameters and bone mineral density
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Yoon Young-Nam
Lee Wan
Lee Byung-Do
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Abstract
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Purpose : Bone mineral density (BMD) and bone microarchitecture are important determinants for bone strength. Recently micro-CT have provided possibilities for measuring a variety of structural indices to characterize bone microarchitecture. The objective of this study was to compare the BMD and micro-CT parameters with Young’s modulus calculated by finite element analysis (FEA) for the evaluation of bone strength.
Materials and Methods : Bone specimens were obtained from the 18 female rabbits aged 16 weeks. Of those, 36
samples (right and left femur) were selected for 3D micro-CT analysis (ANTTM, SKYSCAN, Belgium) and BMD by
PIXImus 2 (GE Lunar Co. USA). Five microstructural parameters of micro-CT, such as trabecular thickness
(Tb.Th), bone specific surface (BS/BV), percent bone volume (BV/TV), structure model index (SMI) and degree of anisotropy (DOA) were studied. Young’s modulus was obtained by software program (ANSYS 9.0, ANSYS Inc,
Canonsburg, PA) based on micro-CT three dimensional images.
Results : Young’s modulus assessed by FEA correlated significantly with Tb.Th, BV/TV, BS/BV and SMI
respectively. Young’s modulus showed higher correlation with these microstructural parameters of micro-CT than BMD. Microstructural parameters except DOA showed significant correlations within the examined group.
Conclusion : The microarchitectural parameters of micro-CT and BMD represented some informations in the
evaluation of bone strength assessed by FEA. (Korean J Oral Maxillofac Radiol 2007; 37 : 53-9)
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KEYWORD
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Computed Tomography, Bone, Finite Element Analysis
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